How SARS-CoV-2 in American deer could alter the course of the global pandemic

[Fun CH]

https://elemental.medium.com/theres-goo ... 2c1fc976c1


"Before you start to doom spiral, though, let’s turn back to good news: Antibodies aren’t the only tools the immune system has to fight repeat invaders"

"Even if “antibody levels are quite low in coronavirus infection, having T cells around to get them up quickly will give you quite a bit of protection.”

[mister_coffee]

More grounds for cautious optimism:

https://jamanetwork.com/journals/jama/f ... le/2781521

Studies using blood samples from people who’d recovered from either SARS or SARS-CoV-2 have provided tantalizing evidence supporting the feasibility of a pancoronavirus vaccine.

Serum from people who’d been infected with SARS-CoV during the 2003 SARS outbreak demonstrated cross-reactive neutralizing activity against the SARS-CoV-2 spike protein, while serum from people recovered from COVID-19 showed cross-reactive neutralizing activity against both SARS-CoV and MERS.

Why individuals who’d been infected with 1 coronavirus could produce neutralizing antibodies against other coronaviruses relates to the evolutionary biology principle of conservation: the presence of similar genes or gene parts in different members of, in this case, virus families. The stability of these family heirlooms, so to speak, makes them attractive pancoronavirus vaccine targets.

[mister_coffee]

I think there is some grounds for cautious optimism:

https://www.nytimes.com/2021/02/09/heal ... ccine.html

Coronaviruses are similar enough to each other, Dr. Topol said, that it might not be that hard to build vaccines that make broadly neutralizing antibodies. “This is an easy family of viruses to take down,” he said.

[PAL]

Ok, understand. Thanks for the reply. Yes, I do agree, those more vulnerable would benefit from the shot. I am really healthy but I did go ahead and get the shot. The reason being, is I didn't want to find out that I am not healthy enough, if I contracted this thing. I probably am, but didn't want to take the chance. Plus my husband is older, and healthy, but a light smoker. He read that smokers may be more vulnerable.
There may be no stopping this virus. Will there be such a thing as herd immunity?
I do wonder what implications it has, for the animal population(I know we're animals too)
I guess time will tell.
Pearl

[dorankj]

I repeated here that because this virus had animal vectors (unlike smallpox, the only respiratory virus we’ve been able to eliminate via vaccine) that it would be impossible to stop this via vaccine. The shot is really a therapeutic for vulnerable people who have a high potential for severe reaction or death (similar to flu shots).

[PAL]

From the other BB where Ray's post is.

"There were the Gorillas in the San Diego zoo. They are reporting out breaks in the Big Cats at the National zoo and Bronx zoo. Despite protocols to prevent transmission it still jumped from us humans to those animals it happened."

So does this mean it is important, more than ever, to become vaccinated? Either to help the animals from getting it(too late now, I would think) or to help humans not get it from animals? And to prevent hospitalization or severe illness.

Ken, you said shocking; you were feigning shock? and asked who said this long ago. I can't think of who might have talked about this long ago, except for the scientists that dealt with other pandemics and viruses long ago. Would like to know who.
Pearl

[dorankj]

Shocking! Who said this long ago?

[pasayten]

It's getting complicated...

NPR November 10, 20215:29 PM ET
MICHAELEEN DOUCLEFF


Scientists have evidence that SARS-CoV-2 spreads explosively in white-tailed deer, and the virus is widespread in this deer population across the U.S.

Researchers say the findings are quite concerning and could have vast implications for the long-term course of the global pandemic.

Since SARS-CoV-2 first emerged, there have been several signs that white-tailed deer would be highly susceptible to the virus — and that many of these animals were catching it across the country.

In September last year, computer models suggested SARS-CoV-2 could easily bind to and enter the deer's cells. A recent survey of white-tailed deer in the Northeast and Midwest found that 40% of them had antibodies against SARS-CoV-2.

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Now veterinarians at The Pennsylvania State University have found active SARS-CoV-2 infections in at least 30% of deer tested across Iowa during 2020. The study, published online last week, suggests that white-tailed deer could become what's known as a reservoir for SARS-CoV-2. That is, the animals could carry the virus indefinitely and spread it back to humans periodically.

If that's the case, it would essentially dash any hopes of eliminating or eradicating the virus in the U.S. — and therefore in the world — says veterinary virologist Suresh Kuchipudi at Penn State, who co-led the study.

"If the virus has opportunities to find an alternate host besides humans, which we would call a reservoir, that will create a safe haven where the virus can continue to circulate even if the entire human population becomes immune," he says. "And so it becomes more and more complicated to manage or even eradicate the virus."

In the study, Kuchipudi and his colleagues looked for the presence of SARS-CoV-2 virus in the lymph nodes of nearly 300 white-tailed deer, including more than 100 wild deer. "So these deer were either roadkill or free-living deer that hunters had killed [to eat]," says veterinary microbiologist Vivek Kapur at Penn State, who also co-led the study.


COVID's endgame: Scientists have a clue about where SARS-CoV-2 is headed
What they found left Kapur and Kuchipudi dumbfounded. "It was actually quite stunning to us," Kapur says. "We were very surprised to see such a high number of positive samples."

During April to December of last year, about 30% of the deer that they tested were positive for SARS-CoV-2 by a PCR test. And then during the winter surge in Iowa, from Nov. 23, 2020 to Jan. 10, about 80% of the deer that they tested were infected. At the peak of the surge, Kapur says, the prevalence of the virus in deer was effectively about 50 to 100 times the prevalence in Iowa residents at the time.

During this timeframe, the team also sequenced the genes of nearly 100 samples of the virus. They found the variants circulating in the deer matched the variants circulating in people.

Those genomic sequences suggest that, during the pandemic, deer have caught the virus from people multiple times in Iowa alone, Kapur says. "The data are very consistent again with frequent spillover events from humans into deer and then transmission among the animals."

Virologist Linda Saif at The Ohio State University's College of Veterinary Medicine says humans are likely infecting white-tailed deer across the country. The deer is native to North America, Central America and the northern edge of South America. In the U.S. alone, there are an estimated 30 million animals.

"We also have detected the virus in deer in Ohio," she says. "And there are antibody studies that suggest the prevalence of COVID infections among deer are pretty high in the Midwest and East."

Although the virus doesn't seem to make the animals sick, Saif says, the new data from Iowa are "very concerning."

"Now the question is: Can the virus spill back from deer to humans? Or can deer transmit the virus effectively to grazing livestock? We don't know the answers to those questions yet, but if they are true, they're obviously concerning," she says.


People wonder if they should keep calm and carry on in the face of delta plus variant
Another concern, Saif says, is that SARS-CoV-2 could evolve inside the deer and create new strains of the virus. Researchers have already documented such a scenario with minks on farms in the Netherlands and Poland, she points out.

In those studies, farm workers passed the virus onto captive animals. As the virus spread through the minks, it mutated and created new variants. These new versions of the virus then spilled back to the humans, the researchers reported.

At the end of day, tracking the emergence of new variants may become much more complicated, says Kuchipudi.

"If we want to continue to be proactive about emerging variants — and not be surprised by one that suddenly pops up — there's an urgent need to continue to monitor SARS-CoV-2 in wildlife," he says, "especially in animals that could serve as a reservoir, like the deer."

https://www.npr.org/sections/goatsandso ... l-pandemic